KRT2; KRT2A; KRT2E; Keratin, type II cytoskeletal 2 epidermal; Cytokeratin-2e; Epithelial keratin-2e; Keratin-2 epidermis; Keratin-2e; Type-II keratin Kb2
Key Feature
Clonality
Polyclonal
Isotype
Ig
Host Species
Rabbit
Tested Applications
WB
WB:1:50~100
Species Reactivity
Human
Concentration
1mg/ml
Target Information
Gene Synonyms
KRT2A KRT2E
Alternative Names
KRT2 KRT2A KRT2E Keratin type II cytoskeletal 2 epidermal Cytokeratin-2e Epithelial keratin-2e Keratin-2 epidermis Keratin-2e Type-II keratin Kb2
Molecular Weight(MW)
65433 Da
Function
Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization
Tissue Specificity
Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingiva and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization
Western blot analysis of KRT2A Antibody (N-term) in Jurkat cell line lysates (35ug/lane). KRT2A (arrow) was detected using the purified Pab.
Application Notes
WB:1:50~100
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.