Application
LAIR1 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the LAIR1 antibody detected the LAIR1 protein (arrow).| Product Name | LAIR1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LAIR1; CD305; Leukocyte-associated immunoglobulin-like receptor 1; CD_antigen=CD305; Flags: Precursor |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CD305 |
|---|---|
| Alternative Names | LAIR1 CD305 Leukocyte-associated immunoglobulin-like receptor 1 CD_antigen=CD305 Flags: Precursor |
| Molecular Weight(MW) | 31412 Da |
| Function | Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down- regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells |
| Tissue Specificity | Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Entrez Gene | 3903 |
|---|---|
| Nucleotide Accession | NP_002278.1 NP_068352.1 |
Application
LAIR1 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the LAIR1 antibody detected the LAIR1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
