Application
LEPR Antibody (C-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the LEPR antibody detected the LEPR protein (arrow).| Product Name | LEPR Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LEPR; DB; OBR; Leptin receptor; HuB219; OB receptor; CD_antigen=CD295; Flags: Precursor |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DB OBR |
|---|---|
| Alternative Names | LEPR DB OBR Leptin receptor HuB219 OB receptor CD_antigen=CD295 Flags: Precursor |
| Molecular Weight(MW) | 132494 Da |
| Function | Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity) |
| Tissue Specificity | Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary Low level in lung and kidney. Isoform B is highly expressed in hypothalamus |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Entrez Gene | 3953 |
|---|---|
| Nucleotide Accession | NP_001003680.1 NP_001003679.1 |
Application
LEPR Antibody (C-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the LEPR antibody detected the LEPR protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
