Application
LILRB1 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the LILRB1 antibody detected the LILRB1 protein (arrow).| Product Name | LILRB1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LILRB1; ILT2; LIR1; MIR7; Leukocyte immunoglobulin-like receptor subfamily B member 1; CD85 antigen-like family member J; Immunoglobulin-like transcript 2; Monocyte/macrophage immunoglobulin-like receptor 7; CD_antigen=CD85j; Flags: Precursor |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | ILT2 LIR1 MIR7 |
|---|---|
| Alternative Names | LILRB1 ILT2 LIR1 MIR7 Leukocyte immunoglobulin-like receptor subfamily B member 1 CD85 antigen-like family member J Immunoglobulin-like transcript 2 Monocyte/macrophage immunoglobulin-like receptor 7 CD_antigen=CD85j Flags: Precursor |
| Molecular Weight(MW) | 70819 Da |
| Function | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions |
| Tissue Specificity | Expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells. Detected on a low percentage of T-cells and natural killer (NK) cells |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Entrez Gene | 10859 |
|---|---|
| Nucleotide Accession | NP_001075106.1 NP_001075107.1 |
Application
LILRB1 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the LILRB1 antibody detected the LILRB1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
