Application
LIN7C Antibdy (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LIN7C Antibdy (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.Application
LIN7C Antibody (C-term) western blot analysis in MCF-7,NCI-H292 cell line lysates (35ug/lane).This demonstrates the LIN7C antibody detected the LIN7C protein (arrow).| Product Name | LIN7C Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LIN7C; MALS3; VELI3; Protein lin-7 homolog C; Mammalian lin-seven protein 3; Vertebrate lin-7 homolog 3 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| IHC:1:10~50 WB |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | MALS3 VELI3 |
|---|---|
| Alternative Names | LIN7C MALS3 VELI3 Protein lin-7 homolog C Mammalian lin-seven protein 3 Vertebrate lin-7 homolog 3 |
| Molecular Weight(MW) | 21834 Da |
| Function | Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells |
| Tissue Specificity | This LIN7C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-197 amino acids from the C-terminal region of human LIN7C. |
| Cellular Localization | Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Peripheral membrane protein (By similarity). Cell junction, tight junction (By similarity) Cell junction, synapse, synaptosome (By similarity). Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells |
| Entrez Gene | 55327 |
|---|---|
| Nucleotide Accession | NP_060832.1 |
Application
LIN7C Antibdy (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LIN7C Antibdy (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Application
LIN7C Antibody (C-term) western blot analysis in MCF-7,NCI-H292 cell line lysates (35ug/lane).This demonstrates the LIN7C antibody detected the LIN7C protein (arrow).| Application Notes | IHC:1:10~50 WB |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
