Application
Western blot analysis of LINGO-1(LRRN6A) in mouse liver tissue lysates (35ug/lane).LRRN6A (arrow) was detected using the purified Pab.Application
LINGO-1(LRRN6A)-S596 (C-term) Antibody IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the LINGO-1(LRRN6A)-S596 (C-term) Antibody for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | LINGO-1(LRRN6A)-S596 (C-term) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Lingo1; Lern1; Lrrn6a; Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Lern1 Lrrn6a |
|---|---|
| Alternative Names | Lingo1 Lern1 Lrrn6a Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 Leucine-rich repeat neuronal protein 1 Leucine-rich repeat neuronal protein 6A |
| Molecular Weight(MW) | 69101 Da |
| Function | Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development |
| Tissue Specificity | Highly specific expression in the central nervous system. Predominant expression in neocortex, amygdala, hippocampus, thalamus and entorhinal cortex, with lower levels in cerebellum and basal nuclei |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Entrez Gene | 235402 |
|---|
Application
Western blot analysis of LINGO-1(LRRN6A) in mouse liver tissue lysates (35ug/lane).LRRN6A (arrow) was detected using the purified Pab.
Application
LINGO-1(LRRN6A)-S596 (C-term) Antibody IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the LINGO-1(LRRN6A)-S596 (C-term) Antibody for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
