Application
LRP5 Antibody (C-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the LRP5 antibody detected the LRP5 protein (arrow).| Product Name | LRP5 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LRP5; LR3; LRP7; Low-density lipoprotein receptor-related protein 5 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | LR3 LRP7 |
|---|---|
| Alternative Names | LRP5 LR3 LRP7 Low-density lipoprotein receptor-related protein 5 |
| Molecular Weight(MW) | 179145 Da |
| Function | Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation |
| Tissue Specificity | Widely expressed, with the highest level of expression in the liver and in aorta |
| Cellular Localization | Membrane; Single-pass type I membrane protein. Endoplasmic reticulum (By similarity). Note=Chaperoned to the plasma membrane by MESD (By similarity) |
| Entrez Gene | 4041 |
|---|---|
| Nucleotide Accession | NP_002326.2 |
Application
LRP5 Antibody (C-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the LRP5 antibody detected the LRP5 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
