| Product Name | 15 deoxy Delta 12,14 Prostaglandin J2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to 15 deoxy Delta 1214 Prostaglandin J215-deoxy-Delta12,14-Prostaglandin J2 (15-d-PGJ2) is one of the ultimate dehydration products of PGD2, formed via the intermediate Delta12-PGJ2. 15-d-PGJ2 is physiologically present in body fluids at concentration of 10-12 to 10-9 M, but increases dramatically under stress such as infection and inflammation. 15-d-PGJ2 exerts both pro- and anti-inflammatory effects in a cell-type and concentration-dependent manner, with many of these effects mediated via binding to the gamma isoform of the peroxisome proliferators-activated receptor (PPAR-gamma). 15-d-PGJ2 appears to induce HO-1 expression by a PPAR-gamma-independent mechanism mediated by the generation of reactive oxygen species (ROS). |
| Immunogen | 15-deoxy-D12,14-Prostaglandin J2 conjugated to a protein carrier molecule |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISARIA |
| Working dilutions are best determined by the end user.: |
|
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Gene Synonyms | Prostaglandin J2 |
|---|---|
| Target | 15 deoxy Delta 12,14 Prostaglandin J2 |
| Tissue Specificity | This antibody detects Prostaglandin J2 (25.3 %), Prostaglandin D2 (13.13 %), D12-Prostaglandin J2 (8.89 %) and 9a,11b-Prostaglandin F2 alpha (6.93 %). |
| Application Notes | Working dilutions are best determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Upon receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | PBS with 0.1% sodium azide |
