Application
IHC-P analysis of human colon/rectum adenocarcinoma using 4-1BBL / CD137L antibody at a concentration of 0.25 mg/ml. An HRP-labeled polymer detection system was used with a DAB chromogen. Proteinase K antigen retrieval is recommended.| Product Name | 4-1BBL / CD137L antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to 4-1BBL / CD137LThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008] |
| Immunogen | Recombinant Human 4-1BB Ligand |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHCIHC-PWB |
| IHC:1:50~1:200 IHC-P:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | tumor necrosis factor (ligand) superfamily member 9 4-1BB-L TNFSF9 CD137L |
|---|---|
| Target | 4-1BBL / CD137L |
Application
IHC-P analysis of human colon/rectum adenocarcinoma using 4-1BBL / CD137L antibody at a concentration of 0.25 mg/ml. An HRP-labeled polymer detection system was used with a DAB chromogen. Proteinase K antigen retrieval is recommended.| Application Notes | IHC:1:50~1:200 IHC-P:1:50~1:200 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS, pH 7.2 |
