Application
Western blot analysis of extracts from rat liver cells, using ADAM 17 (Cleaved-Arg215) Antibody. The lane on the right is treated with the synthesized peptide.| Product Name | ADAM17 (cleaved Arg215) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to ADAM 17 (cleaved Arg215)Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ADAM 17. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| ELISA: 1:20000Optimal dilutions should be determined experimentally by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | MGC71942 CSVP CD156B ADAM18 ADAM 17 TACE ADAM17 ADAM 17 (cleaved R215) ADAM 17 (cleaved Arg215) ADAM 17 cleaved R215 ADAM 17 cleaved Arg215 Cleaved ADAM 17 (R215) Cleaved ADAM 17 (Arg215) |
|---|---|
| Target | ADAM 17 |
| Molecular Weight(MW) | 65 kDa (note) |
| Tissue Specificity | ADAM 17 (Cleaved-Arg215) Antibody detects endogenous levels of fragment of activated ADAM 17 resulting from cleavage adjacent to Arg215. |
Application
Western blot analysis of extracts from rat liver cells, using ADAM 17 (Cleaved-Arg215) Antibody. The lane on the right is treated with the synthesized peptide.| Application Notes | ELISA: 1:20000Optimal dilutions should be determined experimentally by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20 degrees Celcius. Product is stable for at least 1 year. |
| Storage Buffer | Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
