Application
Immunohistochemical staining of human tissue sections using ADAMTS4 antibody| Product Name | ADAMTS4 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to A Disintegrin-like and Metalloprotease with Thrombospondin Type 1 Motif 4 (ADAMTS4)ADAMTS4, also known as aggrecanase-1, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan and the brain extracellular matrix proteoglycan brevican. The ADAMTS4 protein contains a signal sequence, a propeptide domain, a catalytic domain, a disintegrin-like motif, and a C-terminal domain with a thrombospondin (TSP) type 1 motif. ADAMTS4 has been implicated in inflammatory joint diseases, and it also may be a factor in the progression of glioma and Alzheimer's disease. ADAMTS4 expression has been documented in normal human brain, cartilage, heart, lung, placenta, muscle, and synovium. ESTs have been isolated from human tissue libraries, including normal brain, lung, pancreas, and skeletal muscle and cancerous breast. |
| Immunogen | Synthetic peptide - KLH conjugated. Peptide sequence identity/similarity to Mouse: 100/100%. Rat: 93/93%. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-P |
| IHC-P:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | ADAM-TS4 Adamts4 ADMP1 ADMP-1 240913 ADAMTS-2 3830423K05 ADAMTS2 mKIAA0688 ADMP 1 ADAM TS4 ADAMTS 2 |
|---|---|
| Target | ADAMTS4 |
Application
Immunohistochemical staining of human tissue sections using ADAMTS4 antibody| Application Notes | IHC-P:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Phosphate buffered saline, pH 7.4, containing 0.01% sodium azide |
