Application
B. Immunohistochemical analysis of paraffin-embedded human fetal liver using anti-AFP Rab pAb (cat. #).Application
A. Western blot analysis on HepG2 cell lysate of using anti-AFP (C-term) Rabbit Polyclonal (cat. # ) dilution 1:50000| Product Name | Alpha fetoprotein / AFP antibody, C-term |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to Alpha-fetoprotein (C-term)Alpha-fetoprotein (AFP) is a serum glycoprotein protein produced in the liver or yolk sac of fetal staged mammals. AFP synthesis is minimal after birth and a trace amount is expressed in the adult liver . AFP gene expression is regulated by the interactions between steroid hormone receptors and transcriptional factors in separate signal transduction pathways . AFP functions as a binding and transporting ligand and cell growth regulator. An elevated expression level of AFP has been implicated in colorectal, ovarian, pancreatic, testicular, and certain liver cancers. A high level of AFP is also seen in some diseases, such as hepatitis and colitis. AFP is used as a screening marker for fetal abnormalities in pregnant women, such as Down syndrome. Recently, AFP has been introduced as an anti-cancer drug-ligand carrier, transporting drugs to target tumor cells, increasing anti-tumor efficiency . |
| Immunogen | A synthetic peptide corresponding to residues in C-terminus of human AFP was used as an immunogen. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| For WB: 1/1000 - 1/10000.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | HPAFP FETA AFP Alpha fetoprotein Alphafetoprotein |
|---|---|
| Target | Alpha-fetoprotein (C-term) |
| Molecular Weight(MW) | 70 (note) |
Application
B. Immunohistochemical analysis of paraffin-embedded human fetal liver using anti-AFP Rab pAb (cat. #).
Application
A. Western blot analysis on HepG2 cell lysate of using anti-AFP (C-term) Rabbit Polyclonal (cat. # ) dilution 1:50000| Application Notes | For WB: 1/1000 - 1/10000.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20 °C. Stable for 12 months from date of receipt. |
| Storage Buffer | 1X PBS containing Sodium azide 0.01%, Glycerol 50% and BSA 0.05%. |
