Application
Western blot analysis of Androgen Receptor (pY363) expression in LNCaP (A); MCF7 UV-treated (B); mouse spleen (C); rat spleen (D) whole cell lysates.| Product Name | Androgen Receptor (phospho Tyr363) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to Androgen Receptor (phospho Tyr363)The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Androgen Receptor. The exact sequence is proprietary. |
| Modification | p-Tyr363 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB: 1:500 - 1:1000 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | TFM , DHTR , KD , HYSP1 , AR8 , SBMA , AIS , SMAX1 , HUMARA , AR , androgen receptor , NR3C4 |
|---|---|
| Target | Androgen Receptor |
| Tissue Specificity | Recognizes endogenous levels of Androgen Receptor (pY363) protein. |
Application
Western blot analysis of Androgen Receptor (pY363) expression in LNCaP (A); MCF7 UV-treated (B); mouse spleen (C); rat spleen (D) whole cell lysates.| Application Notes | WB: 1:500 - 1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4 C. Upon delivery aliquot and store at -20 C for one year. Avoid freeze/thaw cycles. |
| Storage Buffer | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. |
