Rabbit polyclonal antibody to AOS-1 (SUMO1 activating enzyme subunit 1)Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM]
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human AOS-1. The exact sequence is proprietary.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WB
*Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity
Human
Predicted Reactivity
ChimpanzeeChimpanzee (100%)
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
AOS1 antibody, FLJ3091 antibody, HSPC140 antibody, SUA1 antibody, UBLE1A antibody, SAE1 antibody, activator of SUMO1 antibody, sentrin/SUMO-activating protein AOS1 antibody, ubiquitin-like protein SUMO-1 activating enzyme antibody, SUMO-activating enzyme s
Target
AOS-1
Molecular Weight(MW)
38 kDa (note)
Cellular Localization
Nucleus
Application
Application
Sample (30 ug of whole cell lysate) A: A549 10% SDS PAGE diluted at 1:1000
Positive Control
A549 , HCT116
Application Notes
*Optimal dilutions/concentrations should be determined by the researcher.
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.