Application
Western blot analysis of APC (pS2054) expression in HeLa (A); Caco2 (B); SW480 (C); MCF7 (D); SP2/0 (E); PC12 (F) whole cell lysates.| Product Name | APC (phospho Ser2054) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to APC (phospho Ser2054)This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human APC. The exact sequence is proprietary. |
| Modification | p-Ser2054 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB: 1:500 - 1:1000 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | DP2.5 , DP2 , GS , adenomatous polyposis coli , DP3 , BTPS2 , APC , PPP1R46 |
|---|---|
| Target | APC |
| Tissue Specificity | Recognizes endogenous levels of APC (pS2054) protein. |
Application
Western blot analysis of APC (pS2054) expression in HeLa (A); Caco2 (B); SW480 (C); MCF7 (D); SP2/0 (E); PC12 (F) whole cell lysates.| Application Notes | WB: 1:500 - 1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4 C. Upon delivery aliquot and store at -20 C for one year. Avoid freeze/thaw cycles. |
| Storage Buffer | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. |
