Rabbit polyclonal antibody to API5This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human API5, different from the related mouse sequence by one amino acid.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-FIHC-PWB
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
apoptosis inhibitor 5 , AAC-11 , AAC11
Target
API5
Application
Application
WB analysis of rat cardiac muscle lysate using API5 antibody.
Application
IHC-P analysis of human epidermic carcinoma using API5 antibody.
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Aliquot and store at -20ºC. Avoid multiple freeze-thaw cycles.