Rabbit polyclonal antibody to APLP1This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Immunogen
Recombinant protein of human APLP1
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ICC/IFIHC-PWB
WB: 1:500 - 1:2000. IHC: 1:50 - 1:100.
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
amyloid beta (A4) precursor-like protein 1 , APLP
Target
APLP1
Molecular Weight(MW)
72kD (note)
Application
Application
WB analysis of extracts from various cell lines using APLP1 antibody.
Application
ICC/IF analysis of HeLa cells using APLP1 antibody (green) and DAPI (blue).
Application Notes
WB: 1:500 - 1:2000. IHC: 1:50 - 1:100.
Additional Information
Form
Liquid
Storage Instructions
Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles.