| Product Name | APP antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to APPThis gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IPWB |
| Western Blotting: 1/500 - 1/1000 Optimal dilution / concentration should be determined by the end user. | |
| Species Reactivity | HumanMouseMonkey |
| Concentration | 1mg/ml |
| Purification | Serum |
| Gene Synonyms | PN-II , AD1 , ABETA , CTFgamma , APPI , ABPP , CVAP , PN2 , AAA , amyloid beta (A4) precursor protein |
|---|---|
| Target | APP |
| Tissue Specificity | This antibody recognizes all forms of human amyloid precursor protein and does not recognise bovine APP. |
| Application Notes | Western Blotting: 1/500 - 1/1000 Optimal dilution / concentration should be determined by the end user. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage Buffer | 0.1%Sodium Azide |
