Application
Immunofluorescence of ARMER in Mouse Intestine cells with ARMER antibody at 2 ug/mL.Application
Western blot ana-lysis of ARMER in mouse small intestine tissue lysates with ARMER antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.Application
Immunohistochemical staining of human bladder tissue using ARMER antibody at 2 ug/ml.| Product Name | ARMER antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to ARMERApoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA (1). Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12 (2), other caspases such as caspase-9 are also thought to be activated following ER stress (3). Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity (3), although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains. |
| Immunogen | Synthesis peptide corresponding to a region within amino acids 153 and 203 of human ARL6IP (Uniprot ID# Q15041) |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFIHC-PWB |
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | AIP1, ARMER, ARL6IP |
|---|---|
| Target | ARMER |
| Tissue Specificity | This antibody is specific for ARMER C-Terminus |
Application
Immunofluorescence of ARMER in Mouse Intestine cells with ARMER antibody at 2 ug/mL.
Application
Western blot ana-lysis of ARMER in mouse small intestine tissue lysates with ARMER antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Application
Immunohistochemical staining of human bladder tissue using ARMER antibody at 2 ug/ml.| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS containing 0.02% sodium azide |
