Application
axin 2 antibody [N2C2], Internal detects axin 2 protein at cytoplasm in rat brain by immunohistochemical analysis. Sample: Paraffin-embedded rat brain. axin 2 antibody [N2C2], Internal diluted at 1:500.Application
axin 2 antibody [N2C2], Internal detects axin 2 protein at cytosol on mouse hind brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse hind brain. axin 2 antibody [N2C2], Internal dilution: 1:500.| Product Name | axin 2 antibody , Internal |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to axin 2 (axin 2 (conductin, axil))The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq] |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human axin 2. The exact sequence is proprietary. |
| Clonality | Polyclonal |
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| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| *Optimal dilutions/concentrations should be determined by the researcher.
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| Species Reactivity | HumanMouseRat |
| Predicted Reactivity | Chicken, BovineChicken (80%), Bovine (80%) |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | AXIL antibody DKFZp781B0869 antibody MGC10366 antibody MGC126582 antibody AXIN2 antibody axin-like protein antibody axin-2 antibody axis inhibition protein 2 antibody conductin antibody axin 2 antibody |
|---|---|
| Target | axin 2 |
| Molecular Weight(MW) | 94 kDa (note) |
| Cellular Localization | Cytoplasm |
Application
axin 2 antibody [N2C2], Internal detects axin 2 protein at cytoplasm in rat brain by immunohistochemical analysis. Sample: Paraffin-embedded rat brain. axin 2 antibody [N2C2], Internal diluted at 1:500.
Application
axin 2 antibody [N2C2], Internal detects axin 2 protein at cytosol on mouse hind brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse hind brain. axin 2 antibody [N2C2], Internal dilution: 1:500.| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
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| Form | Liquid |
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| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
