| Product Name | BACE1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to BACE1Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis Alzheimer's disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor(APP) at b- and g-sites by two proteases. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all sufferers of Alzheimer's disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). bACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP. |
| Immunogen | Synthetic peptide, corresponding to amino acids 485-501 of Human BACE.The peptide sequence differs fromthose of mouse and rat BACE by one amino acid (1). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western blot: 1:500 - 1:1000, detects the 70 kD band of BACE.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 0.5mg/ml |
| Gene Synonyms | BACE1 ASP2 P56817 23621 604252 KIAA1149 BACE HSPC104 |
|---|---|
| Target | BACE |
| Cellular Localization | Plasma membrane |
| Positive Control | Human brain tissue lysate. |
|---|---|
| Application Notes | Western blot: 1:500 - 1:1000, detects the 70 kD band of BACE.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Upon receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide |
