Application
Sample (30 ug of whole cell lysate) A: Molt-4 5% SDS PAGE diluted at 1:1000Application
Immunohistochemical analysis of paraffin-embedded H441 xenograft, using Bcr antibody at 1:500 dilution.| Product Name | Bcr antibody , C-term |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to Bcr (breakpoint cluster region)A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human Bcr. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| *Optimal dilutions/concentrations should be determined by the researcher.
: |
|
| Species Reactivity | Human |
| Predicted Reactivity | MouseMouse (96%) |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | ALL antibody BCR1 antibody CML antibody D22S11 antibody D22S662 antibody FLJ16453 antibody PHL antibody BCR antibody breakpoint cluster region protein antibody renal carcinoma antigen NY-REN-26 antibody breakpoint cluster region antibody |
|---|---|
| Molecular Weight(MW) | 143 kDa (note) |
Application
Sample (30 ug of whole cell lysate) A: Molt-4 5% SDS PAGE diluted at 1:1000
Application
Immunohistochemical analysis of paraffin-embedded H441 xenograft, using Bcr antibody at 1:500 dilution.| Positive Control | Molt-4 |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
