Application
Sample (30 ug of whole cell lysate) A: NT2D1 B: PC-3 C: U87-MG 7.5% SDS PAGE diluted at 1:1000Application
Immunohistochemical analysis of paraffin-embedded U87 xenograft, using Bestrophin 1 antibody at 1:500 dilution.| Product Name | Bestrophin 1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to Bestrophin 1 (bestrophin 1)This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms. |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human Bestrophin 1. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| *Optimal dilutions/concentrations should be determined by the researcher.
: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | ARB antibody BEST antibody BMD antibody RP50 antibody TU15B antibody VMD2 antibody BEST1 antibody vitelliform macular dystrophy protein 2 antibody Best disease antibody bestrophin-1 antibody bestrophin 1 antibody |
|---|---|
| Molecular Weight(MW) | 68 kDa (note) (4) |
| Cellular Localization | Cell membrane |
Application
Sample (30 ug of whole cell lysate) A: NT2D1 B: PC-3 C: U87-MG 7.5% SDS PAGE diluted at 1:1000
Application
Immunohistochemical analysis of paraffin-embedded U87 xenograft, using Bestrophin 1 antibody at 1:500 dilution.| Positive Control | NT2D1 , PC-3 , U87-MG |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
