| Product Name | Bestrophin antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal to BestrophinBestrophin is a 68 kDa basolateral plasma membrane protein encoded by the VMD2 gene. The role of Bestrophin is as yet unclear but it is thought to be involved in Best Macular Dystrophy (BMD) or Vitelliform Macular Dystrophy (VMD2); inherited early onset autosomal forms of macular degeneration. There is evidence to suggest that Bestrophin is a chloride channel that plays a role in generating the altered electrooculogram in Best disease patients. |
| Immunogen | Synthetic peptide: WKLKAVDAFKSAPLYQRPGY, corresponding to amino acids 445-464 of Human Bestrophin. The peptide was amidated for conjugation. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICC/IFIHCIPWB |
| ICC: Use at an assay dependent dilution. IHC: Use at an assay dependent dilution, GTX14928 stains weakly. IP: Use at a dilution of 1/200. GTX14928 immunoprecipitates poorly. WB: Use at a dilution of 1/500. Predicted molecular weight: 68 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | HumanMonkeyRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | BEST VMD2 Bestrophin 7439 O76090 153700 TU15B BMD |
|---|---|
| Target | Bestrophin |
| Cellular Localization | Plasma membrane |
| Positive Control | Conditioned medium cultured RPE cells (the basal expression of Bestrophin is low in cultured cells). |
|---|---|
| Application Notes | ICC: Use at an assay dependent dilution. IHC: Use at an assay dependent dilution, GTX14928 stains weakly. IP: Use at a dilution of 1/200. GTX14928 immunoprecipitates poorly. WB: Use at a dilution of 1/500. Predicted molecular weight: 68 kDa. Optimal dilutions/concentrations should be determined by the end user.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
