Application
Western Blot: Bestrophin 1 Antibody (E6-6) - Detection of Bestrophin (68 kDa) from human RPE cell lysate.| Product Name | Bestrophin antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal to BestrophinBest macular dystrophy (BMD) or vitelliform macular dystrophy (VMD2), is an autosomal form of macular degeneration, characterized by a depressed light peak in the electrooculogram (EOG). It is inherited and has an early onset. Bestrophin is a 68 kDa basolateral plasma membrane protein encoded by the VMD2 gene. Bestrophin's function is still unknown, but data suggests that it is a chloride channel that plays a role in generating the altered EOG in Best disease patients. In addition, Bestrophin is a useful biochemical and histological marker of RPE (retinal pigment epithelial cells) cells. |
| Immunogen | Partial recombinant protein [KDHMDPYWALENRDEAHS] |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | ICC/IFIHC-FIHC-PIPWB |
| Western Blot: 1:1000, Immunocytochemistry/Immunofluorescence Assay dependent, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunoprecipitation.: |
|
| Species Reactivity | HumanMonkey |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | BEST VMD2 Bestrophin 7439 O76090 153700 TU15B BMD ARB RP50 |
|---|---|
| Target | Bestrophin |
| Tissue Specificity | This antibody is specific for Bestrophin. |
| Light Chain Type | kappa |
Application
Western Blot: Bestrophin 1 Antibody (E6-6) - Detection of Bestrophin (68 kDa) from human RPE cell lysate.| Positive Control | Pig RPE (Retinal Pigment Epithelium) whole cell extract (clone E6-1 or E6-6) |
|---|---|
| Application Notes | Western Blot: 1:1000, Immunocytochemistry/Immunofluorescence Assay dependent, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunoprecipitation.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Upon receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
