Application
Western blot analysis of extracts of BT474 cell line, using BTRC antibody.Application
Immunohistochemistry of paraffin-embedded human stomach using BTRC antibody at dilution of 1:200 (x400 lens)| Product Name | beta-TrCP antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to beta-TrCPThis gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript v |
| Immunogen | Recombinant protein of human BTRC |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICC/IFIHCIHC-PWB |
| WB: 1:500 - 1:2000, IHC: 1:50 - 1:200 , IF: 1:50 - 1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | bTrCP1 , FBXW1 , BTRC , FWD1 , bTrCP , FBW1A , beta-transducin repeat containing E3 ubiquitin protein ligase , FBXW1A , betaTrCP , BETA TRCP |
|---|---|
| Target | beta-TrCP |
Application
Western blot analysis of extracts of BT474 cell line, using BTRC antibody.
Application
Immunohistochemistry of paraffin-embedded human stomach using BTRC antibody at dilution of 1:200 (x400 lens)| Application Notes | WB: 1:500 - 1:2000, IHC: 1:50 - 1:200 , IF: 1:50 - 1:200 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
