Rabbit polyclonal to BMP8The Bone morphogenetic proteins (BMPs) are members of the TGF beta superfamily of cytokines that are involved in development, differentiation, and disease. The transforming growth factor beta (TGF beta) super-family consists of a large number of growth and differentiation factors, such as TGF betas, activins, inhibins, growth and differentiation factors (GDFs), and bone morphogenetic proteins (BMPs). The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4. BMP8 Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. It also plays a role in calcium regulation and bone homeostasis.
Immunogen
Synthetic peptide: LQTLRAGDEGWLVL conjugated to KLH, corresponding to amino acids 184-197 of BMP8.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
DotELISAWB
Dot: Use at a dilution of 1/2000. ELISA: Use at a dilution of 1/2000. WB: Use at a dilution of 1/500 - 1/1000. Detects a band of approximately 45 kDa. Optimal dilutions/concentrations should be determined by the end user.
Species Reactivity
HumanMouseRat
Concentration
0.5mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
656, 602284, P34820, BMP8, BMP8B, OP2, MGC131757
Target
BMP8
Cellular Localization
Secreted
Application
Application
WB of BMP8 with Antibody dilution 1:500 in diluObuffer. Apparent MW of BMP8 is 49kDa
Application Notes
Dot: Use at a dilution of 1/2000. ELISA: Use at a dilution of 1/2000. WB: Use at a dilution of 1/500 - 1/1000. Detects a band of approximately 45 kDa. Optimal dilutions/concentrations should be determined by the end user.
Additional Information
Form
Liquid
Storage Instructions
Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.