| Product Name | BMPR2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [9A10] to BMPR2This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008] |
| Immunogen | Recombinant BMP RII extra cellular domain |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 9A10 |
| Host Species | Mouse |
| Tested Applications | IHCWB |
| WB(1:100-1000)|IHC(1:50-200): |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | BMPR3 BMPR-II BMR2 BRK-3 BMPR2 PPH1 T-ALK bone morphogenetic protein receptor type II (serine/threonine kinase) |
|---|---|
| Target | BMPR II |
| Tissue Specificity | This antibody was selected for its ability to detect human BMPR2. No cross reactivity was found to hBMP R1A and R1B. |
| Application Notes | WB(1:100-1000)|IHC(1:50-200): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
