Rabbit monoclonal antibody [EP152Y] to B-RafThis gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008]
Immunogen
Synthetic peptide: CGEHNPPSIYLEAYEEYT , corresponding to N terminal amino acids 70-86 of Human B Raf
Key Feature
Clonality
Monoclonal
Isotype
IgG
Clone Number
EP152Y
Host Species
Rabbit
Tested Applications
FACS,IHC-P,IP,WB
Species Reactivity
Human,Mouse,Rat
Concentration
1mg/ml
Target Information
Gene Synonyms
B-RAF1 , BRAF , BRAF1 , RAFB1 , NS7
Target
B-Raf
Application
Application
IHC-P analysis of human prostate cancer tissue using B-Raf antibody [EP152Y] at a dilution of 1:250.
Additional Information
Form
Liquid
Storage Instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage Buffer
PBS containing 50% Glycerol, 0.05% BSA and 0.01% Sodium azide.