| Product Name | BRCA1 (phospho Ser1189) antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to BRCA1 (phospho Ser1189)BRCA1 is a breast cancer susceptibility gene that was localized to chromosome 17q. Mutations within this gene are believed to account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. Like many other genes involved in familial cancer, BRCA1 appears to encode a tumor suppressor, a protein that acts as a negative regulator of tumor growth. |
| Modification | p-Ser1189 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western blotting (1-2 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been tested yet. Detect human BRCA1 when phosphorylated at Ser1189. | |
| Species Reactivity | Human |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | Breast Cancer Gene 1, Early Onset, phospho BRCA1 (pSer1189), BRCA1, phospho BRCA1 (pS1189), phospho-BRCA1 (pS1189), phosphoBRCA1 (pS1189), BreastOvarian Cancer Susceptibility, phosphoBRCA1 (pSer1189), phospho-BRCA1 (pSer1189), pho, Breast Cancer Gene1, Bre |
|---|---|
| Target | BRCA1 (phospho Ser1189) |
| Tissue Specificity | This antibody is specific for BRCA1 (phospho Ser1189). |
| Cellular Localization | Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex. |
| Application Notes | Western blotting (1-2 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been tested yet. Detect human BRCA1 when phosphorylated at Ser1189. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | The antibody solution should be gently mixed before use. Store at +4C. Product should remain stable for at least 12 months. |
| Storage Buffer | PBS (pH 7.2) containing 50% glycerol, 1% BSA, 0.02% thimerosal |
