Application
IHC-P analysis of human breast carcinoma using BRCA2 antibody at a dilution of 1:200.| Product Name | BRCA2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to BRCA2Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008] |
| Immunogen | KLH conjugated synthetic peptide derived from human BRCA2 (19-60aa) |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC-P |
| IHC-P(1:100-500) | |
| Species Reactivity | Human |
| Predicted Reactivity | Bovine, Rabbit, Horse, Chicken, Dog |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | FANCB, FACD, FANCD1, BRCC2, GLM3, BROVCA2, FANCD, FAD1, PNCA2, FAD, breast cancer 2, early onset |
|---|---|
| Target | BRCA2 |
| Tissue Specificity | BRCA2/FANCB |
Application
IHC-P analysis of human breast carcinoma using BRCA2 antibody at a dilution of 1:200.| Application Notes | IHC-P(1:100-500) |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and less than 0.09% sodium azide. |
