Application
Immunofluorescence of BRSK2 in Human Brain cells with BRSK2 antibody at 20 ug/mL.Application
Western blot analysis of BRSK2 in human brain tissue lysate with BRSK2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.Application
Immunohistochemistry of BRSK2 in human brain tissue with BRSK2 antibody at 5 ug/ml.| Product Name | BRSK2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to BRSK2BRSK2 was initially identified through a computer screen of the human genome and shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK2 is expressed in the brain and to a lesser extent in the testes. BRSK2 is a member of the AMP-activated protein kinase subfamily and can be activated by the tumor suppressor kinase LKB1. More recently, it has been shown that both BRSK2 and the related protein BRSK1 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. BRSK2 has also been shown to be an autoantigen in paraneoplastic limbic encephalitis. At least four isoforms of BRSK2 are known to exist. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISA,ICC/IF,IHC-P,WB |
| Species Reactivity | Human,Mouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | BR serine-threonine kinase 2, serinethreonine protein kinase 29, SAD1B kinase, serine-threonine protein kinase 29, STK29 PEN11B, BRSK2, SAD-A, SADA, BR serinethreonine kinase 2, serinethreonine protein kinase29, BR serinethreonine kinase2, SAD A, BR serin |
|---|---|
| Target | BRSK2 |
| Tissue Specificity | This antibody is specific for BRSK2 |
Application
Immunofluorescence of BRSK2 in Human Brain cells with BRSK2 antibody at 20 ug/mL.
Application
Western blot analysis of BRSK2 in human brain tissue lysate with BRSK2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Application
Immunohistochemistry of BRSK2 in human brain tissue with BRSK2 antibody at 5 ug/ml.| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Antibody is supplied in PBS containing 0.02% sodium azide |
