| Product Name | C Reactive Protein antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [C6] to C Reactive ProteinC Reactive Protein is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is a pentraxin (cyclic pentameric protein) compound of five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa), that are bound noncovalently to form the physiologic CRP molecule (m.w. 117.5 kDa). C Reactive Protein mediates activities associated with preimmune nonspecific host resistance. It is opsonic, an initiator of the classical complement cascade and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. Studies have revealed that among other markers of inflammation, CRP shows the strongest association with cardiovascular events. Many clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. Measurements of C-reactive protein (hsCRP) in the patients with ischemic heart disease provide a novel method for detecting individuals at high risk of plaque rapture. |
| Immunogen | Full length native protein (purified) (Human) |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Clone Number | C6 |
| Host Species | Mouse |
| Tested Applications | ELISA |
| ELISA: Use at an assay dependent concentration. Can be paired for ELISA with GTX28277 Mouse monoclonal [C2] to C Reactive Protein , GTX28279 Mouse monoclonal [C5] to C Reactive Protein or GTX28278 Mouse monoclonal [C6] to C Reactive Protein as capture. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Synonyms | CRP 123260 PTX1 MGC88244 C Reactive Protein P02741 1401 |
|---|---|
| Target | C Reactive Protein |
| Tissue Specificity | Human CRP |
| Cellular Localization | Secreted |
| Application Notes | ELISA: Use at an assay dependent concentration. Can be paired for ELISA with GTX28277 Mouse monoclonal [C2] to C Reactive Protein , GTX28279 Mouse monoclonal [C5] to C Reactive Protein or GTX28278 Mouse monoclonal [C6] to C Reactive Protein as capture. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. We recommend to parafilm vials during storage to prevent evaporation of buffer. |
| Storage Buffer | PBS, pH 7.4, 0.09 % sodium azide (NaN3) |
