Rabbit Polyclonal antibody to C/EBP alphaThe C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues.? These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP.? One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells.? Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation.? From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients.
Immunogen
Recombinant protein corresponding to residues 466-813 of rat C/EBP alpha.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
IP,WB
WB: 2 ug/ml Optimal dilution / concentration should be determined by the end user.
Species Reactivity
Human,Mouse
Concentration
1mg/ml (Please refer to the vial label for the specific concentration)