Application
Human Thyroid Medullary Carcinoma stained with anti-Calcitonin antibodyApplication
Formalin fixed paraffin embedded human thyroid medullary carcinoma stained with Calcitonin antibody (cat. # ).Application
Human lung adenocarcinoma stained with anti-Calcitonin antibodyApplication
Human thyroid medullary carcinoma stained with anti-Calcitonin antibodyApplication
Human pituitary stained with anti-Calcitonin antibody| Product Name | Calcitonin antibody (ready-to-use) |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Monoclonal Rabbit Antibody to Human Calcitonin (ready-to-use)This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Immunogen | Synthetic human calcitonin 1-32 amino acid peptide. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Clone Number | SP17 |
| Host Species | Rabbit |
| Tested Applications | IHCIHC-P |
| We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CGRPI KC P01258 796 CALC1 CGRP-I CALCA CT CGRP1 Calcitonin CGRP MGC126648 114130 CGRP I |
|---|---|
| Target | Calcitonin |
| Tissue Specificity | This antibody recognizes Calcitonin, which is a 32 amino acid peptide, which can be demonstrated in C cells of the normal and hyperplastic thyroid. Staining for calcitonin may be used for the identification of a spectrum of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors. Staining for calcitonin in medullary carcinoma of the thyroid produces a fine granular pattern in the cytoplasm. Amyloid deposits within the tumor may also exhibit varying degrees of calcitonin activity. This antibody crossreacts with Human, Monkey, Mouse, Rat, Dog, Horse, Sheep and Pig. |
| Cellular Localization | Cytoplasmic |
Application
Human Thyroid Medullary Carcinoma stained with anti-Calcitonin antibody
Application
Formalin fixed paraffin embedded human thyroid medullary carcinoma stained with Calcitonin antibody (cat. # ).
Application
Human lung adenocarcinoma stained with anti-Calcitonin antibody
Application
Human thyroid medullary carcinoma stained with anti-Calcitonin antibody
Application
Human pituitary stained with anti-Calcitonin antibody| Positive Control | Thyroid or Medullary carcinoma |
|---|---|
| Application Notes | We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
