| Product Name | Cardiac Troponin I antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [MF4] to cardiac Troponin ITroponin I is part of a heteromeric complex playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, troponin I (TnI), troponin T (TnT) and troponin C (TnC). Each subunit is responsible for part of troponin complex function. E.g. TnI inhibits ATP-ase activity of acto-myosin. TnT and TnI are presented in cardiac muscles in different forms than in skeletal muscles. Only one tissue-specific isoform of TnI is described for cardiac muscle tissue (cTnI). cTnI is expressed only in myocardium. |
| Immunogen | epitope:190 – 196 a.a of human cardiac Troponin I |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | MF4 |
| Host Species | Mouse |
| Tested Applications | PurifyELISAWB |
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| Species Reactivity | HumanDogPigRatCatGoatBovine |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Synonyms | 7137 CMH7 TNNI3 Cardiac Troponin I cTnI 115210 P19429 TNNC1 MGC116817 |
|---|---|
| Target | Cardiac Troponin I |
| Tissue Specificity | This antibody is reacting with free cardiac troponin I (cTnI) and cTnI forming complexes with other troponin components (In the presence of 5 mM EDTA). It is not affected by heparin, phosphorylation, oxidation and troponin complex formation.This antibody does not cross-react with skeletal muscle troponin I. |
| Application Notes | : |
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| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Preservative: 0.1% Sodium Azide; Constituents: PBS. pH 7.4 |
