| Product Name | Caspase 1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal to Caspase 1/Interleukin-1 Converting Enzyme (ICE)Caspase 1/ICE (Interleukin-1 a Converting Enzyme) is expressed as a proenzyme of 45 kD in many tissues. Upon stimulus it gets activated by proteolytic cleavage. Active Caspase 1 is a tetramer of two subunits p10 and p20 in 2;2 proportion. Caspase 1 (Cystein Aspartic-Specific Protease 1) cleaves its substrates after an aspartate residue. It cleaves Interleukina into its active form which further exerts its proinflammatory effects. Overexpression of Caspase 1 can induce apoptosis in fibroblast which can be inhibited by overexpression of Crm A, a protein from pox virus. |
| Immunogen | A synthetic peptide from the second quarter of human Caspase 1 protein |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IHC-P |
| For IHC-P: Use at a dilution of 1:1,000. Optimal dilutions/concentrations should be determined by the researcher.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | 147678 IL1BC ICE P29466 P45 Caspase1 Caspase 1 834 CASP1 |
|---|---|
| Target | Caspase 1 |
| Cellular Localization | Nuclear and Cytoplasmic |
| Positive Control | Placenta |
|---|---|
| Application Notes | For IHC-P: Use at a dilution of 1:1,000. Optimal dilutions/concentrations should be determined by the researcher.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. |
| Storage Buffer | 10mM Phosphate-bufferd saline containing 0.2% BSA and 0.1% sodium azide |
