| Product Name | Caspase 7 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [B4 - G2] to Caspase 7The caspase family of cysteine proteases plays a key role in apoptosis. Caspase 7, also known as Mch3a, ICE/LAP3 and CMH1, is a 34 kDa protein that is activated during Fas- and TNF-induced apoptosis. Caspase 7 has been identified as a major contributor to the execution phase of cellular apoptosis. It cleaves essential cellular machinery following its own cleavage from an inactive proenzyme to an active heterodimeric form. Caspase 7 is processed by caspase 3, 6, 8, 9, and 10 as well as by Granzyme B. |
| Immunogen | Available on request. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | B4-G2 |
| Host Species | Mouse |
| Tested Applications | IPWB |
| IP: Use at a concentration of 4 - 10 μg/ml. WB: Use at a concentration of 0.5 - 2 μg/ml. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 0.5mg/ml |
| Gene Synonyms | ICELAP3 ICE-LAP3 CMH-1 CASP7 CMH1 601761 Caspase 7 840 Caspase7 P55210 MCH3 CMH 1 ICE LAP3 |
|---|---|
| Target | Caspase 7 |
| Tissue Specificity | This antibody detects both pro-caspase 7 (34 kDa) and the large subunit of cleaved caspase 7 (19 kDa) in apoptosis cells on SDS-PAGE immunoblots. |
| Cellular Localization | Cytoplasmic |
| Application Notes | IP: Use at a concentration of 4 - 10 μg/ml. WB: Use at a concentration of 0.5 - 2 μg/ml. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | PBS with 1 mg/ml BSA, 1.5 mM thimerosal and 50% glycerol |
