Application
Various tissue extracts (75 µg) were separated by 5% SDS-PAGE, and the membrane was blotted with Caspr1 antibody diluted at 1:1000.| Product Name | CASPR antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit Polyclonal antibody to CASPR (contactin associated protein-like 1)Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells. Mice that lack CNTAP1 exhibit tremor, ataxia, and significant motor paresis. Normal paranodal junctions fail to form, and the organization of the paranodal loops is disrupted. Contactin is undetectable in the paranodes, and potassium channels are displaced from the juxtaparanodal into the paranodal domains. Also results in a severe decrease in peripheral nerve conduction velocity. |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of mouse CASPR. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| *Optimal dilutions/concentrations should be determined by the researcher.
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| Species Reactivity | MouseRat |
| Predicted Reactivity | Rhesus MonkeyRhesus Monkey (83%) |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | AI841080 antibody Caspr1 antibody Cntnap1 antibody NCP1 antibody Nrxn4 antibody contactin associated protein-like 1 antibody p190 antibody shm antibody |
|---|---|
| Target | CASPR |
| Molecular Weight(MW) | 156 kDa (note) |
| Cellular Localization | Membrane |
Application
Various tissue extracts (75 µg) were separated by 5% SDS-PAGE, and the membrane was blotted with Caspr1 antibody diluted at 1:1000.| Positive Control | mouse brain , rat brain |
|---|---|
| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative. |
