| Product Name | CCR1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [7B17] to CCR1This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008] |
| Immunogen | Human CCR1 transfected 293 cells |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | 7B17 |
| Host Species | Mouse |
| Tested Applications | IHCWB |
| FC(1:100-800)|IHC(1:50-200): |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | CKR1 HM145 MIP1aR SCYAR1 CKR-1 CD191 chemokine (C-C motif) receptor 1 CMKBR1 |
|---|---|
| Target | CCR1 |
| Tissue Specificity | This antibody was selected for its ability to detect human CCR1 not other CCRs |
| Application Notes | FC(1:100-800)|IHC(1:50-200): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
