| Product Name | CD105 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [1G2] to CD105CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2. |
| Immunogen | CML blast crisis cells. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG3 |
| Clone Number | 1G2 |
| Host Species | Mouse |
| Tested Applications | FACS |
| FACS: Use 2μg for 10^5 cells. Optimal dilutions/concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 0.2mg/ml |
| Purification | Protein A |
| Gene Synonyms | ORW CD105 P17813 HHT1 131195 2022 END ENG ORW1 |
|---|---|
| Target | CD105 |
| Tissue Specificity | 1G2 stains endothelial cells from various tissues and syncytiotrophoblasts. Stains intensely on high endothelial venules (HEV), but does not react with peripheral blood cells, this antibody recognizes specifically proerythroblasts from bone marrow. |
| Cellular Localization | Cell Membrane |
| Application Notes | FACS: Use 2μg for 10^5 cells. Optimal dilutions/concentrations should be determined by the end user.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Storage Buffer | Preservative: None. Constituents: PBS, 1mg/ml BSA |
