| Product Name | CD158d antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse Monoclonal antibody [mAb#33] to CD158dCD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-γ secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.Entrez Gene: 19q13.4 |
| Immunogen | NK3.3 cells and KIR2DL4-Ig fusion protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | mAb#33 |
| Host Species | Mouse |
| Tested Applications | FACSICC/IFIPWBFunctional Assay |
| FACS: Use at 1 µg/mL: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | 103AS 15.212 CD158D KIR103 KIR103AS KIR2DL4 |
|---|---|
| Target | CD158d |
| Tissue Specificity | The mouse monoclonal antibody mAb#33 (also known as mAb 33 or 33) recognizes extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depends on genotype of particular individuals. |
| Application Notes | FACS: Use at 1 µg/mL: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 2-8°C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles. |
| Storage Buffer | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
