Application
Sample(30 ug whole cell lysate) A:A431 B:H1299 10% SDS PAGE diluted at 1:1000| Product Name | CD158e antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Rabbit polyclonal antibody to CD158e (killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1)Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq] |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human CD158e. The exact sequence is proprietary. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| *Optimal dilutions/concentrations should be determined by the researcher.
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| Species Reactivity | Human |
| Predicted Reactivity | ChimpanzeeChimpanzee (90%) |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Affinity purified |
| Gene Synonyms | CD158E1 antibody KIR antibody KIR3DL1/S1 antibody MGC119726 antibody MGC119728 antibody MGC126589 antibody MGC126591 antibody NKAT3 antibody NKB1 antibody NKB1B antibody KIR3DL1 antibody CD158 antigen-like family member E antibody MHC class I N |
|---|---|
| Target | CD158e |
| Molecular Weight(MW) | 49 kDa (note) (2) |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
Application
Sample(30 ug whole cell lysate) A:A431 B:H1299 10% SDS PAGE diluted at 1:1000| Positive Control | A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji |
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| Application Notes | *Optimal dilutions/concentrations should be determined by the researcher.
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| Form | Liquid |
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| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
