| Product Name | CD2 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [MT9-10] to CD2CD2 is a surface antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is implicated in the triggerring of T cells, the cytoplasmic domain is implicated in the signaling function. It is useful for the identification of lymphomas and leukaemias of T cell origin. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | MT9-10 |
| Host Species | Mouse |
| Tested Applications | IHC-FIPWB |
| For IHC-Fr: A dilution of 1:50 to 1:100 may be used as a guideline using a three-step avidin complex system. For WB: Use at an assay dependent dilution. For IP: Use at an assay dependent dilution. Not suitable for use on formalin-fixed, paraffin-embedded sections. The optimal conditions should be determined by the individual laboratory.: |
|
| Species Reactivity | Human |
| Concentration | 0.2mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | 186990 CD2 SRBCR LFA2 914 SRBC T11 P06729 SRBC-R LFA-2 FLJ46032 SRBC R LFA 2 |
|---|---|
| Target | CD2 |
| Tissue Specificity | This antibody reacts with the E-rosette receptor on T-cells. The receptor, which has a molecular weight of approximately 50 kD, is present on the surface of the majority of circulating T-cells. This antibody reacts with the majority of T-cells in peripheral lymphoid tissue, cortical thymocytes, and most T-cell neoplasms |
| Light Chain Type | kappa |
| Application Notes | For IHC-Fr: A dilution of 1:50 to 1:100 may be used as a guideline using a three-step avidin complex system. For WB: Use at an assay dependent dilution. For IP: Use at an assay dependent dilution. Not suitable for use on formalin-fixed, paraffin-embedded sections. The optimal conditions should be determined by the individual laboratory.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. |
| Storage Buffer | Phosphate-buffered saline, pH 7.2, containing 0.2% BSA and 0.09% sodium azide |
