Application
IHC image using - Detection of CD21 by IHC in human tonsilApplication
Formalin fixed paraffin embedded human tonsil stained with CD21 antibody (cat. # ).| Product Name | CD21 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal [1F8] to CD21CD21 also known as complement receptor 2 (CR2). C3d receptor or EBV receptor is a 140 kDa protein. CD21 is a glycosylated type I transmembrane protein consisting of an extracellular face of a series of 15 or 16 CCP domains. CD21 is the receptor for complement components C3d and iC3b as well as the Epstein-Barr virus (EBV) glycoprotein gp350/220. The soluble CD21 (sCD21) was shown to efficiently trigger CD23-signalling pathways in human monocytes. By inducing release of proinflammatory cytokines and upregulating expression of molecules involved in antigen presentation, sCD21 modulates critical monocyte functions that may be relevant to allergic and inflammatory disorders. |
| Immunogen | Purified receptor for the C3d fragment of the third complement component CR2. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 1F8 |
| Host Species | Mouse |
| Tested Applications | IHCIHC-FIHC-P |
| Immunohistochemistry: use at a dilution of 1 / 10 - 1 / 25 for 30 - 60 mins at RT (ABC method). Optimal dilutions / concentrations should be determined by the end user.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CD21 120650 1380 CR2 P20023 C3DR SLEB9 |
|---|---|
| Target | CD21 |
| Tissue Specificity | This antibody reacts with CD21 antigen of MW 145 kDa, present on the surface of mature B cells. The antigen is present at high density on follicular dendritic cells. CD21 is involved in transmitting growth promoting signals to the interior of the B cell. |
| Cellular Localization | Cell membrane. |
| Light Chain Type | kappa |
Application
IHC image using - Detection of CD21 by IHC in human tonsil
Application
Formalin fixed paraffin embedded human tonsil stained with CD21 antibody (cat. # ).| Positive Control | Tonsil |
|---|---|
| Application Notes | Immunohistochemistry: use at a dilution of 1 / 10 - 1 / 25 for 30 - 60 mins at RT (ABC method). Optimal dilutions / concentrations should be determined by the end user.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. |
| Storage Buffer | This antibody contains sodium azide as a preservative. |
