| Product Name | CD26 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse Monoclonal antibody [BA5b] to CD26CD26, also known as dipeptidyl peptidase IV (DPP-IV), is a homodimeric cell surface serine peptidase that degradates IFN-gamma-induced cytokines, acts as a T cell costimulatory molecule, and participates in multiple immunopathological roles in leukocyte homing and inflammation. Alterations in its peptidase activity are characteristic of malignant transformation. The enzymatic activity increases dramatically with tumour grade and severity. CD26 is expressed in various blood cell types, but also e.g. in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.Entrez Gene: 2q24.3 |
| Immunogen | A human T cell clone |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Clone Number | BA5b |
| Host Species | Mouse |
| Tested Applications | FACS |
| FACS: Use at 1.5 µg/mL. Positive Control:human peripheral blood leukocytes: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | ADABP ADCP2 CD26 DPPIV TP103 |
|---|---|
| Target | CD26 |
| Tissue Specificity | The mouse monoclonal antibody BA5b recognizes CD26, a 110 kDa type II membrane glycoprotein, which is a peptidase expressed on mature thymocytes, T cells (especially activated), B cells, NK cells and macrophages. |
| Cellular Localization | Detected in the serum and the seminal fluid. Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids. Redistributed to membrane rafts in T-ce |
| Application Notes | FACS: Use at 1.5 µg/mL. Positive Control:human peripheral blood leukocytes: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 2-8°C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles. |
| Storage Buffer | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
