| Product Name | CD40 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse monoclonal antibody [9F21] to CD40The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| Immunogen | human recombinant CD40 extra cellular domain |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | 9F21 |
| Host Species | Mouse |
| Tested Applications | ELISAFACSIHCWB |
| Immunocytochemetry(1:50-500)|WB(1:100-1000)|FC(1:50): |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Synonyms | TNFRSF5 p50 CD40 molecule TNF receptor superfamily member 5 Bp50 CDW40 |
|---|---|
| Target | CD40 |
| Tissue Specificity | This antibody was selected for its ability to detect human CD40 by ELISA. |
| Application Notes | Immunocytochemetry(1:50-500)|WB(1:100-1000)|FC(1:50): |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | PBS |
