Mouse monoclonal antibody [PM6/248] to CD41ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Clone Number
PM6/248
Host Species
Mouse
Tested Applications
FACS
FACS:1:200~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher.
This antibody recognizes free CD41 or CD41 only when complexed with CD61.
Application
Application
FACS ImageStaining of human peripheral blood platelets with Mouse anti Human CD41:FITC
Application
FACS ImageStaining of human peripheral blood platelets with Mouse anti Human CD41:RPE
Application Notes
FACS:1:200~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher.
Additional Information
Form
Liquid
Storage Instructions
Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.