Mouse monoclonal antibody [PM6/248] to CD41ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Clone Number
PM6/248
Host Species
Mouse
Tested Applications
FACS
Flow Cytometry: 1/100 - 1/200 Optimal dilution / concentration should be determined by the end user.:
This antibody recognizes free CD41 or CD41 only when complexed with CD61.
Application
Application
FACS ImageStaining of human peripheral blood platelets with Mouse anti Human CD41:RPE
Application
FACS ImageStaining of human peripheral blood platelets with Mouse anti Human CD41:FITC
Application Notes
Flow Cytometry: 1/100 - 1/200 Optimal dilution / concentration should be determined by the end user.:
Additional Information
Form
Liquid
Storage Instructions
Store at -20°C only. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.