Rabbit polyclonal antibody to CD74The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Immunogen
Recombinant protein of human CD74
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
IHC-PWB
WB: 1:500 - 1:2000. IHC: 1:50 - 1:200.:
Species Reactivity
Human
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Gene Synonyms
HLADG DHLAG Ia-GAMMA II CD74 molecule major histocompatibility complex class II invariant chain
Target
CD74
Molecular Weight(MW)
33 kDa (note)
Application
Application
WB analysis of extracts from various cell lines using CD74 antibody.
Application Notes
WB: 1:500 - 1:2000. IHC: 1:50 - 1:200.:
Additional Information
Form
Liquid
Storage Instructions
Store at -20°C (regular) or -80°C (long term). Avoid freeze / thaw cycles.